Key result
In patients with coronary artery disease, serum leptin was a significant independent predictor of arterial stiffness (OR 1.026 per 1 ng/ml increase) and correlated positively with the number of stenotic vessels.
Cross-Sectional (n=105)
No
Odds Ratio: 1.026 (95% CI 1.002–1.051)
p-value: p=0.037
Higher serum leptin levels are independently associated with increased central arterial stiffness and correlate with the number of stenotic coronary arteries in patients with coronary artery disease.
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Does not support leptin measurement in CAD care; hypothesis-generating, needs prospective studies before any clinical role.
Tsai et al. (2016) conducted a cross-sectional in Coronary artery disease (n=105). Serum leptin levels was evaluated on Arterial stiffness (cfPWV > 10 m/s) (OR 1.026, 95% CI 1.002-1.051, p=0.037). In patients with coronary artery disease, serum leptin was a significant independent predictor of arterial stiffness (OR 1.026 per 1 ng/ml increase) and correlated positively with the number of stenotic vessels.
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