Key result
Elevated leptin levels were independently associated with increased arterial stiffness, as measured by augmentation index (adjusted coefficient 0.268, p=0.001), in a community population.
Why the study?
Are elevated leptin levels associated with increased arterial stiffness in a community population free of overt cardiovascular disease?
Cross-Sectional (n=97)
No
Are elevated leptin levels associated with increased arterial stiffness in a community population free of overt cardiovascular disease?
Effect estimate: coefficient st = 0.268
p-value: p=0.001
Elevated leptin levels are independently associated with increased arterial stiffness in a community population, suggesting a potential mechanism for increased cardiovascular risk.
Purpose: Leptin plays a regulatory role in body weight by controlling appetite and energy consumption. Elevated plasma leptin levels (hyperleptinemia) have been suggested to contribute to pathogenesis of diabetes, hypertension, atherosclerosis and coronary heart disease. Arterial stiffness is an independent predictor of cardiovascular risk. We investigated the differential effects of adiponectin, leptin and resistin levels on wave reflections, an index of arterial stiffness in a community population sample. Methods: The study population consisted of 97 subjects (mean age: 46.4±10.5 yrs, 57M/40F), 28 subjects were hypertensives, 22 subjects had dyslipidemia, 4 suffered from diabetes and 32 individuals were obese. Subjects were free of overt cardiovascular disease. Wave reflections were evaluatedwith augmentation index (AIx) of the aortic pressure waveform using commercially available system. Leptin, adiponectin and resistin levels were measured by ELISA kit. Results: Leptin was associated with AIx (r=0.409, P<0.001) and Tr (an index of pulse wave velocity, r=-0.385, P<0.001). Levels of resistin and adiponectin were not correlated with AIx and Tr. After adjustment for confounding factors (age, brachial systolic pressure, fasting glucose, total cholesterol, weight, height, heart rate and hsCRP) leptin levels were independently associated with AIx (R2=0.605, coefficient st=0.268p=0.001). Conclusion: In contrast to other adipocytokines, leptin levels were associated with arterial stiffness, independently of other confounding factors. Given the prognostic role of arterial stiffness for cardiovascular events, these findings are important to further characterize the increase of cardiovascular risk in subjects with elevated levels of leptin.
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Baou et al. (2009) conducted a cross-sectional in Healthy or asymptomatic community population (n=97). Elevated leptin levels vs. Normal or lower leptin levels was evaluated on Arterial stiffness measured by augmentation index (AIx) (coefficient st = 0.268, p=0.001). Elevated leptin levels were independently associated with increased arterial stiffness, as measured by augmentation index (adjusted coefficient 0.268, p=0.001), in a community population.
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