Key result
Circulating concentrations of retinol-binding protein 4 and leptin receptor were positively associated with mean arterial pressure in fully adjusted models (P<0.002 for both).
Why the study?
Are circulating adipokines associated with vascular stiffness in adults free of cardiovascular disease?
Population
3505 Framingham Third Generation cohort participants free of cardiovascular disease, mean age 40 years, 53%…
Design
Cross-sectional
Authors
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Supports adipokine role in obesity-hypertension link; hypothesis-generating and should not change practice.
Cross-Sectional (n=3,505)
Are circulating adipokines associated with vascular stiffness in adults free of cardiovascular disease?
p-value: p=<0.002
Circulating concentrations of select adipokines are associated with vascular stiffness, supporting their potential role in the link between obesity and hypertension.
Zachariah et al. (2015) conducted a cross-sectional in Free of cardiovascular disease (n=3,505). Circulating adipokines (leptin, leptin receptor, adiponectin, retinol-binding protein 4, and fatty acid-binding protein 4) was evaluated on Vascular stiffness measured by arterial tonometry (mean arterial pressure and aortic stiffness) (p=<0.002). Circulating concentrations of retinol-binding protein 4 and leptin receptor were positively associated with mean arterial pressure in fully adjusted models (P<0.002 for both).
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