April 1, 1996Pain

Effects of cardiac vagal afferent electrostimulation on the responses of trigerninal and trigeminothalamic neurons to noxious orofacial stimulation

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Why the study?

Does cardiac vagal afferent stimulation modulate the responses of trigeminal sensory neurons to noxious orofacial stimulation in anesthetized cats?

Population

37 trigeminal and trigeminothalamic neurons recorded from trigeminal nucleus caudalis and trigeminal nucleus…

Comparison

Cardiac vagal afferent stimulation, either… vs Neuronal responses to noxious orofacial…

Design

Preclinical

Authors

DBDaniel F. BossutUniversity of North Carolina at Chapel Hill WMWilliam MaixnerDaVita Clinical Research (United States)

Discussion

Member takes

Implication

Supports vagal-trigeminal nociception links in animals; leaves open translation to clinical orofacial pain management.

Structured PICO

Does cardiac vagal afferent stimulation modulate the responses of trigeminal sensory neurons to noxious orofacial stimulation in anesthetized cats?

Population

37 trigeminal and trigeminothalamic neurons recorded from trigeminal nucleus caudalis and trigeminal nucleus oralis in alpha-chloralose-anesthetized cats

Intervention

Cardiac vagal afferent stimulation (CVAS), either continuous (5 Hz, 3 msec, 2 mA) or intermittent (7 pulses at 333 Hz, 5 mA, delivered 200 msec prior to test stimulus)

Comparator

Neuronal responses to noxious orofacial stimulation without CVAS

Outcome

Neuronal responses to noxious heat (50 degrees C) or electrical stimulation of facial skin and tooth pulpsurrogate

Cardiac vagal afferent stimulation modulates trigeminal neuronal responses to noxious orofacial stimulation, providing evidence that cardiopulmonary dynamics can influence nociception.

Cite This Study

Bossut et al. (1996) studied this question.

synapsesocial.com/papers/6a8b2afae3303121f0f4467a https://doi.org/10.1016/0304-3959(95)00166-2

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Effects of cardiac vagal afferent electrostimulation on the responses of trigerninal and trigeminothalamic neurons to noxious orofacial stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of cardiac vagal afferent electrostimulation on the responses of trigerninal and trigeminothalamic neurons to noxious orofacial stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider