Key result
Measles virus from the brains of MIBE patients was genetically very similar to the epidemic strain, lacking typical persistent mutation features, but two patients shared a unique L454W mutation in the fusion protein.
Population
4 highly immuno-compromised HIV patients with measles inclusion body encephalitis and 6 acutely infected…
Design
Case_series
Authors
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Supports host factors driving MIBE progression in immunocompromised patients; hypothesis-generating for L454W mutation role and requires validation.
Observational (n=10)
No
Absolute Event Rate: 0.87% vs 0.56%
p-value: p=0.19
In highly immuno-compromised patients with MIBE, the brain measles virus remains genetically very similar to the acute epidemic strain, suggesting host factors primarily drive the rapid disease progression.
Hardie et al. (2013) conducted an observational in Measles inclusion body encephalitis (MIBE) (n=10). Measles virus brain infection vs. Acute epidemic measles virus infection was evaluated on Mutation frequency (per 1000 nucleotides) (p=0.19). Measles virus from the brains of MIBE patients was genetically very similar to the epidemic strain, lacking typical persistent mutation features, but two patients shared a unique L454W mutation in the fusion protein.
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