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December 1, 2000The Journal of PhysiologyOpen Access

Responses of aortic depressor nerve‐evoked neurones in rat nucleus of the solitary tract to changes in blood pressure

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Population

Anaesthetized, paralysed and artificially ventilated rats

Design

Preclinical

Authors

JZJing ZhangUniversity of Nebraska Medical CenterSMSteven W. MifflinUniversity of the Incarnate Word

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Implication

Supports rate-sensitive baroreflex signaling in animal NTS; leaves open translation to human cardiovascular regulation.

Structured PICO

P
Population
Anaesthetized, paralysed and artificially ventilated rats
I
Intervention
Blood pressure changes induced by I.V. phenylephrine or nitroprusside
O
Outcome
Discharge rate of neurones in the nucleus of the solitary tract (NTS) receiving aortic depressor nerve (ADN) inputssurrogate

Monosynaptic neurons in the NTS are sensitive to the rate of change of blood pressure, providing a mechanism for rapid regulation of cardiovascular function.

Cite This Study

Zhang et al. (2000) studied this question.

synapsesocial.com/papers/6a8b2e583fd21775a5339613https://doi.org/10.1111/j.1469-7793.2000.00431.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subthreshold aortic nerve inputs to neurons in nucleus of the solitary tract2000 · 15 citations
  2. 2NTS neuronal responses to arterial pressure and pressure changes in the rat1993 · 88 citations
  3. 3Temporal processing of aortic nerve evoked activity in the nucleus of the solitary tract1996 · 56 citations
  4. 4Baroreceptor inputs to the nucleus tractus solitarius in the cat: postsynaptic actions and the influence of respiration.1988 · 91 citations
  5. 5Arterial chemoreceptor input to nucleus tractus solitarius1992 · 135 citations