Why the study?
Does chronic intermittent hypoxia elicit serotonin-dependent plasticity in the central neural control of breathing in adult rats?
Population
Adult male Sprague Dawley rats, 3-5 months of age.
Comparison
Chronic intermittent hypoxia for 7 consecutive… vs Untreated age-, weight-, and sex-matched control…
Design
Preclinical
Follow-up
Acute experiments conducted 4-8 hours after the 7-night…
Authors
Loading...
Does not yet inform clinical management of sleep-disordered breathing; extends evidence for serotonin-dependent respiratory plasticity in rodents.
Does chronic intermittent hypoxia elicit serotonin-dependent plasticity in the central neural control of breathing in adult rats?
Chronic intermittent hypoxia elicits unique forms of serotonin-dependent plasticity in the central neural control of breathing, enhancing long-term facilitation via non-5-HT2 serotonin receptors.
Ling et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: