Why the study?
What are the separate and combined effects of raising alveolar PCO2 and ventilation on the sensitivity and setting of the baroreceptor cardiodepressor reflex in humans?
Population
6 young men and women trained to control tidal volume and respiratory frequency at various levels…
Comparison
Changes in ventilation and/or alveolar P with… vs Baseline or different combinations of…
Design
Other
Authors
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Alerts clinicians to potential baroreflex variability with ventilation or CO2 changes; leaves open clinical relevance and translation to outcomes.
What are the separate and combined effects of raising alveolar PCO2 and ventilation on the sensitivity and setting of the baroreceptor cardiodepressor reflex in humans?
Hypercapnia and hyperpnoea exert independent effects on baroreflex sensitivity and setting, with significant inter-individual variability.
Bristow et al. (1974) studied this question.
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