Why the study?
Does complete myocardial revascularization improve long-term outcomes compared to incomplete revascularization in patients with multi-vessel coronary artery disease?
Does complete myocardial revascularization improve long-term outcomes compared to incomplete revascularization in patients with multi-vessel coronary artery disease?
The choice between complete and incomplete revascularization in multi-vessel coronary artery disease should be individualized based on patient clinical status, ventricular function, and comorbidities to balance long-term benefits with immediate procedural risks.
May support individualized strategies in multivessel CAD; leaves open need for RCTs to clarify trade-offs.
Myocardial revascularization in patients with multi-vessel coronary artery disease may be accomplished, by percutaneous interventions or surgery, either on all diseased lesions or directed to selectively targeted coronary segments. The extent of planned revascularization is often a major determinant of treatment strategy. Revascularization of all diseased coronary segments-complete myocardial revascularization-has a potential long-term benefit, but is more complex and may increase in-hospital untoward events. Revascularization may otherwise be incomplete, either because of the operator's inability to treat all diseased coronary segments or by choice of deciding to selectively revascularize only large areas of myocardium at risk. Although incomplete revascularization may negatively affect long-term outcomes, it may be, when wisely chosen, the preferred treatment strategy in selected patient categories because of its lower immediate risks. The patient's clinical status, ventricular function, and the presence of co-morbidities may orient clinical decisions in favour of incomplete revascularization.
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Zimarino et al. (2005) studied this question.
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