April 29, 2014PLoS ONEOpen Access

Possible Role of Non-Muscle Alpha-Actinins in Muscle Cell Mechanosensitivity

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Population

Fibers of the soleus muscle and cardiomyocytes of Wistar rats

Design

Preclinical

Follow-up

Up to 72 hours

Authors

IOIrina V. OgnevaInstitute of Biomedical Problems NBNikolay S. Biryukov TLToomas A. LeinsooKurchatov Institute

Discussion

Member takes

Implication

Mechanical unloading may redistribute alpha-actinins and reduce rat cardiomyocyte stiffness; leaves open relevance to human cardiac remodeling.

Structured PICO

Population

Fibers of the soleus muscle and cardiomyocytes of Wistar rats

Intervention

Antiorthostatic suspension of the animals by their tails for 6, 12, 18, 24 and 72 hours

Outcome

Transversal stiffness, beta-, gamma-actin, alpha-actinin 1 and alpha-actinin 4 levels in membranous and cytoplasmic fractions, and expression rates of the corresponding genessurrogate

Changes in external mechanical load via antiorthostatic suspension alter the distribution and expression of non-muscle alpha-actinins and actins in rat cardiomyocytes and soleus muscle fibers, correlating with decreased cellular stiffness.

Cite This Study

Ogneva et al. (2014) studied this question.

synapsesocial.com/papers/6a8b8e5ef07ad6ed43b217e4 https://doi.org/10.1371/journal.pone.0096395

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Implication

Mechanical unloading may redistribute alpha-actinins and reduce rat cardiomyocyte stiffness; leaves open relevance to human cardiac remodeling.

Possible Role of Non-Muscle Alpha-Actinins in Muscle Cell Mechanosensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Possible Role of Non-Muscle Alpha-Actinins in Muscle Cell Mechanosensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider