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January 1, 1994Clinical and Experimental Hypertension

Comparative and Combined Efficacy of Doxazosin and Enalapril in Hypertensive Patients

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Why the study?

Does doxazosin or enalapril, alone or in combination, reduce blood pressure in patients with essential hypertension?

Population

20 patients with essential hypertension

Comparison

Doxazosin or enalapril for 7 weeks, followed by… vs Enalapril or doxazosin respectively in the first…

Design

RCT, randomised

Follow-up

14 weeks (two 7-week periods)

Authors

GSGordon S. StokesHJH. J. JohnstonEOE. Obi Okoro

Discussion

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Overview

Supports preferring enalapril for sustained BP control in essential hypertension; extends evidence on order-dependent combination effects with doxazosin.

Structured PICO

Does doxazosin or enalapril, alone or in combination, reduce blood pressure in patients with essential hypertension?

P
Population
20 patients with essential hypertension
I
Intervention
Doxazosin (1-8 mg/day) or enalapril (5-20 mg/day) for 7 weeks, followed by a 7-week combination phase where the initial drug dose was halved and the second agent was titrated
C
Comparator
Enalapril (5-20 mg/day) or doxazosin (1-8 mg/day) respectively in the first phase; monotherapy in the second phase
O
Outcome
Blood pressure responses assessed by clinic measurements 24 hours post-dosesurrogate

In patients with essential hypertension, enalapril provides greater 24-hour blood pressure reduction than doxazosin, though doxazosin may contribute to early blood pressure control when used in combination.

Cite This Study

Stokes et al. (1994) studied this question.

synapsesocial.com/papers/6a8b8f4af19228bbb2fb550fhttps://doi.org/10.3109/10641969409078021
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