Key result
Cardiac neuromodulation offers diverse techniques and promising avenues for managing refractory ventricular arrhythmias and electrical storm, as summarized in this comprehensive review.
Why the study?
Refractory ventricular arrhythmias may persist despite antiarrhythmic medications and catheter ablation, prompting the use and ongoing evolution of cardiac neuromodulation techniques.
This review summarizes the current state and future perspectives of cardiac neuromodulation techniques for managing refractory ventricular arrhythmias.
May inform neuromodulation strategies in refractory electrical storm; leaves open rigorous human trials before adoption.
Electrical storm represents an urgent challenge in electrophysiology. Despite the use of antiarrhythmic medications and catheter ablation, refractory ventricular arrhythmias may persist, prompting the use of neuromodulation. This approach has evolved over the years, facing initial challenges owing to the intricacies of the autonomic nervous system. Animal studies have significantly enhanced our understanding of this system, paving the way for human studies on sympathetic modulation, which gained momentum in the early 2000s and expanded notably in cardiology in the 2010s. Presently, a variety of techniques coexist and offer diverse alternatives. Additionally, there are promising avenues for development that are primarily explored in animal models. This review aims to shed light on the diverse approaches currently available in this field.
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Groussin et al. (2025) conducted a review in Ventricular arrhythmias and electrical storm. Cardiac neuromodulation was evaluated. Cardiac neuromodulation offers diverse techniques and promising avenues for managing refractory ventricular arrhythmias and electrical storm, as summarized in this comprehensive review.
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