Rapid RT-hyper PCR testing for enterovirus can differentiate atypical hand-foot-and-mouth disease from varicella, preventing unnecessary isolation and antiviral treatment in the PICU.
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May support de-escalating varicella precautions via enterovirus RT-hyper PCR in select PICU cases; leaves open need for prospective validation.
Yasui et al. (2013) studied this question.
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