Why the study?
Are there sex-related differences in in vitro platelet aggregation, and are they influenced by hematocrit-related anticoagulant distribution?
Population
22 healthy subjects (11 male and 11 female)
Comparison
In vitro platelet aggregation testing with… vs Male versus female platelets
Design
Preclinical
Authors
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Should not yet change clinical platelet testing; leaves open human translation and in vivo relevance.
Are there sex-related differences in in vitro platelet aggregation, and are they influenced by hematocrit-related anticoagulant distribution?
Female platelets demonstrate increased in vitro reactivity compared to males when using standard citrate anticoagulation, which may be related to differences in hematocrit.
Kelton et al. (1980) studied this question.
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