Why the study?
Does withdrawal of long-term atenolol therapy cause rebound hypertension or increased cardiac adrenergic sensitivity in hypertensive patients?
Population
n=6 hypertensive patients on long-term therapy (19 +/- 3.6 months) with atenolol
Comparison
Withdrawal of atenolol (200 mg once/daily) vs Baseline values (prior to withdrawal)
Design
Case_series
Authors
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Supports safe atenolol withdrawal in this case; hypothesis-generating and should not change practice without prospective data.
Does withdrawal of long-term atenolol therapy cause rebound hypertension or increased cardiac adrenergic sensitivity in hypertensive patients?
Withdrawal of long-term atenolol therapy in hypertensive patients leads to a gradual return of blood pressure and heart rate to baseline without evidence of rebound hypertension.
Webster et al. (1981) studied this question.
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