Population
Sponge transgenic mouse model with a specific disruption of miR-199 in the heart
Design
Preclinical
Authors
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miR-199 inhibition yields physiological hypertrophy in rodents; leaves open therapeutic targeting in human heart failure.
Inhibition of endogenous miR-199 leads to physiological cardiac hypertrophy, likely via PGC1α upregulation, highlighting its role in cardiac homeostasis.
Li et al. (2016) studied this question.
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