Why the study?
Does chronic all-trans retinoic acid (atRA) treatment modulate APJ and apelin expression and reduce blood pressure in spontaneously hypertensive rats?
Does chronic all-trans retinoic acid (atRA) treatment modulate APJ and apelin expression and reduce blood pressure in spontaneously hypertensive rats?
Chronic atRA treatment upregulates APJ and apelin expression and reduces blood pressure in spontaneously hypertensive rats, suggesting a potential mechanism for hypertension management.
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atRA effects on apelin/APJ in SHR are hypothesis-generating; leaves open clinical translation to human hypertension.
Zhong et al. (2004) studied this question.
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