What question did this study set out to answer?

To evaluate in vivo thrombin and plasmin generation in disseminated intravascular coagulation across distinct underlying clinical disorders.

February 1, 1990American Journal of Hematology

Thrombin Vs. Plasmin generation in disseminated lntravascular coagulation associated with various underlying disorders

View Full Paper

Ask AI

Bookmark

Authors

HTHoyu TakahashiHanazono Hospital WTWataru TatewakiNiigata University KWKen WadaHiroshima City Asa Citizens Hospital

Discussion

Member takes

Implication

Observational study reveals distinct thrombin and plasmin activation profiles in patients with disseminated intravascular coagulation, indicating that underlying diseases dictate clotting balance.

Key Points

To evaluate in vivo thrombin and plasmin generation in disseminated intravascular coagulation across distinct underlying clinical disorders.
Measured plasma levels of thrombin-antithrombin III complex (TAT) and plasmin-alpha 2-antiplasmin complex (PAP) alongside standard coagulation and fibrinolytic markers in 80 patients with DIC.
Stratified biomarker levels and TAT/PAP ratios across underlying clinical etiologies including acute promyelocytic leukemia, sepsis, other leukemias, solid cancer, vascular disease, and shock.
Patients with acute promyelocytic leukemia displayed the highest PAP levels, lowest TAT/PAP ratios, and marked reductions in alpha 2-antiplasmin and fibrinogen, signifying severe hyperfibrinolysis.
Patients with sepsis exhibited the highest TAT/PAP ratios and lowest PAP levels without reductions in alpha 2-antiplasmin or fibrinogen, demonstrating impaired fibrinolytic activity.
Patients with solid cancers showed elevated TAT and high TAT/PAP ratios, whereas patients presenting in shock experienced marked simultaneous elevations of both TAT and PAP.

Cite This Study

Takahashi et al. (1990) studied this question.

synapsesocial.com/papers/6a8ba5f49d5fb440a3beb175 https://doi.org/10.1002/ajh.2830330204

View Full Paper

Ask AI

Bookmark

Implication

Observational study reveals distinct thrombin and plasmin activation profiles in patients with disseminated intravascular coagulation, indicating that underlying diseases dictate clotting balance.

Thrombin Vs. Plasmin generation in disseminated lntravascular coagulation associated with various underlying disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

Thrombin Vs. Plasmin generation in disseminated lntravascular coagulation associated with various underlying disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider