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October 1, 1984BloodOpen Access

Thrombin generation in acute promyelocytic leukemia

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Authors

KBK BauerHadassah Medical CenterRRRD RosenbergUniversity of Milan

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Implication

Observational study demonstrates excessive thrombin generation during acute promyelocytic leukemia, indicating marked hemostatic system hyperactivity during induction chemotherapy.

Key Points

  • Quantify in vivo thrombin generation and evaluate markers of hemostatic system activation in patients with acute promyelocytic leukemia and other acute nonlymphocytic leukemias.
  • Measured plasma levels of prothrombin activation fragment (F1 + 2), thrombin-antithrombin complex (TAT), and fibrinopeptide A (FPA) via sensitive radioimmunoassays in 6 patients presenting with acute promyelocytic leukemia (APL) and disseminated intravascular coagulation (DIC).
  • Monitored serial biomarker concentrations during induction chemotherapy and compared baseline levels against 9 individuals with other acute nonlymphocytic leukemia (ANLL) subtypes.
  • Patients with APL showed markedly higher elevations in F1 + 2, TAT, and FPA than patients with other ANLL subtypes, with antileukemic induction therapy frequently triggering further increases in F1 + 2 and TAT levels.
  • Levels of TAT correlated more strongly with FPA in APL than in ANLL, indicating that F1 + 2 elevation provides a more sensitive indicator of hemostatic hyperactivity than FPA in patients with DIC.

Cite This Study

Bauer et al. (1984) studied this question.

synapsesocial.com/papers/6a7cafd7cc6f1443deba628ehttps://doi.org/10.1182/blood.v64.4.791.791
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Also Consider

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  1. 1Hypofibrinogenemic Hemorrhage in Acute Myelogenous Leukemia Treated with Heparin1964 · 78 citations
  2. 2An alternative pathway for fibrinolysis. I. The cleavage of fibrinogen by leukocyte proteases at physiologic pH.1975 · 198 citations
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  5. 5Prophylactic heparin therapy in acute promyelocytic leukemia1978 · 137 citations