What question did this study set out to answer?

To describe the unique cellular morphology and coagulation defects in acute promyelocytic leukemia and evaluate whether these abnormalities distinguish it from other leukemic variants.

June 1, 1964BloodOpen Access

Acute Promyelocytic Leukemia with Fibrinogen and Factor V Deficiencies

View Full Paper

Ask AI

Bookmark

To describe the unique cellular morphology and coagulation defects in acute promyelocytic leukemia and evaluate whether these abnormalities distinguish it from other leukemic variants.
Evaluated clinical progression, response to 6-mercaptopurine, and coagulation factor kinetics in 2 patients with acute promyelocytic leukemia.
Assayed plasma fibrinogen, factor V, and prothrombin levels in 86 patients presenting with other leukemia subtypes prior to initiation of treatment or during relapse.
Both acute promyelocytic leukemia patients achieved complete remission on 6-mercaptopurine and survived 8 and 14 months, with severe hypofibrinogenemia, thrombocytopenia, and factor V deficiency resolving during remission and reappearing terminally.
None of the 86 patients with other leukemia types exhibited fibrinogen deficiency, and only 8 demonstrated isolated prothrombin or factor V deficiency.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Case series demonstrates severe fibrinogen and factor V deficiencies in acute promyelocytic leukemia, indicating a unique coagulopathy that distinguishes this subtype from other leukemias.

Cite This Study

Didisheim et al. (1964) studied this question.

synapsesocial.com/papers/6a1d8d4f5a0c5c56ea04faf6 https://doi.org/10.1182/blood.v23.6.717.717

View Full Paper

Ask AI

Bookmark

Implication

Case series demonstrates severe fibrinogen and factor V deficiencies in acute promyelocytic leukemia, indicating a unique coagulopathy that distinguishes this subtype from other leukemias.

Acute Promyelocytic Leukemia with Fibrinogen and Factor V Deficiencies

Key Points

Discussion

Implication

Cite This Study

Acute Promyelocytic Leukemia with Fibrinogen and Factor V Deficiencies

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider