Innate immune response to encephalomyocarditis virus infection mediated by CD1d

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Population

CD1d-deficient mice and wild-type (WT) mice infected with encephalomyocarditis virus (EMCV-D)

Comparison

CD1d deficiency, with additional experiments… vs Wild-type (WT) mice

Design

Preclinical

Authors

Discussion

CD1d may support innate antiviral defense in mice; leaves open its relevance to human picornaviral infections.

Population

CD1d-deficient mice and wild-type (WT) mice infected with encephalomyocarditis virus (EMCV-D)

Intervention

CD1d deficiency (genetic knockout), with additional experiments using exogenous IL-12 or anti-asialo-GM1 antibody

Comparator

Wild-type (WT) mice

Outcome

Sensitivity to EMCV-D infection and IL-12/IFN-gamma productionsurrogate

CD1d is essential for optimal innate immune responses to acute picornaviral infection by augmenting APC IL-12 production and activating NK cells.

Exley et al. (2003) studied this question.

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