Novel, single-beat approach for determining both end-systolic pressure–dimension relationship and preload recruitable stroke work
Why the study?
Does a single-beat approach accurately estimate ESPDR and PRSW compared to multiple-beat methods in conscious dogs?
Population
14 conscious dogs under various haemodynamic and pathological conditions
Comparison
Single-beat estimation method for end-systolic… vs Multiple-beat method
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Simplifies contractility assessment in animal models; leaves open human validation before clinical use.
Structured PICO
Does a single-beat approach accurately estimate ESPDR and PRSW compared to multiple-beat methods in conscious dogs?
P
Population
14 conscious dogs under various haemodynamic and pathological conditions
I
Intervention
Single-beat estimation method for end-systolic pressure-dimension relationship (ESPDR) and preload recruitable stroke work (PRSW)
C
Comparator
Multiple-beat method
O
Outcome
Correlation between single-beat and multiple-beat ESPDRs and PRSW slope (Mw)surrogate
A novel single-beat approach accurately estimates load-insensitive measures of contractility (ESPDR and PRSW) without requiring multiple beats over a wide volume range.
Cite This Study
Inuzuka et al. (2016) studied this question.