Population
Permeabilized human ventricular myocytes (n=75 myocytes)
Comparison
Peroxynitrite vs Baseline (before application of peroxynitrite)
Design
Preclinical
Authors
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Hypothesis-generating for peroxynitrite-mediated contractile failure; leaves open clinical relevance and targeted interventions.
Peroxynitrite induces contractile dysfunction in human myocardium by selectively nitrating alpha-actinin, a major Z-line protein.
Borbély et al. (2005) studied this question.
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