What is the clinical evidence from this study?

Study design: Other. Intervention: Peroxynitrite. Primary outcome: Myosin functional impairment (MgATPase activity and actin-stimulated ATPase activity).

September 6, 2010Free Radical Research

Peroxynitrite-mediated oxidative modifications of myosin and implications on structure and function

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Key result

Peroxynitrite enhanced basal MgATPase activity up to 2-fold while inhibiting actin-stimulated ATPase activity, highlighting the importance of protein carbonylation in myosin functional impairment.

Population

Myosin (in vitro model)

Design

Preclinical

Authors

TTTeresa TiagoUniversidad de Extremadura PPPedro S. PalmaCentro de Ciências do Mar do Algarve CGCarlos Gutiérrez‐MerinoUniversidad de Extremadura

Discussion

Member takes

Implication

May implicate carbonylation in myosin impairment under oxidative stress; animal data leaves open human cardiac relevance.

Structured PICO

Population

Myosin (in vitro model)

Exposure

Peroxynitrite exposure under different reaction conditions

Outcome

Functional impairment of myosin (MgATPase activity, actin-stimulated ATPase activity, protein carbonylation)surrogate

Protein carbonylation plays a key role in peroxynitrite-induced functional impairment of myosin.

Cite This Study

Tiago et al. (2010) studied this question. Peroxynitrite was evaluated on Myosin functional impairment (MgATPase activity and actin-stimulated ATPase activity). Peroxynitrite enhanced basal MgATPase activity up to 2-fold while inhibiting actin-stimulated ATPase activity, highlighting the importance of protein carbonylation in myosin functional impairment.

synapsesocial.com/papers/6a8c2742524f523decbbb59b https://doi.org/10.3109/10715762.2010.502170

View Full Paper

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September 6, 2010Free Radical Research

Peroxynitrite-mediated oxidative modifications of myosin and implications on structure and function

View Full Paper

Ask AI

Bookmark

Key result

Peroxynitrite enhanced basal MgATPase activity up to 2-fold while inhibiting actin-stimulated ATPase activity, highlighting the importance of protein carbonylation in myosin functional impairment.

Population

Myosin (in vitro model)

Design

Preclinical

Authors

TTTeresa TiagoUniversidad de Extremadura PPPedro S. PalmaCentro de Ciências do Mar do Algarve CGCarlos Gutiérrez‐MerinoUniversidad de Extremadura

Discussion

Member takes

Implication

May implicate carbonylation in myosin impairment under oxidative stress; animal data leaves open human cardiac relevance.

Structured PICO

Population

Myosin (in vitro model)

Exposure

Peroxynitrite exposure under different reaction conditions

Outcome

Functional impairment of myosin (MgATPase activity, actin-stimulated ATPase activity, protein carbonylation)surrogate

Protein carbonylation plays a key role in peroxynitrite-induced functional impairment of myosin.

Cite This Study

synapsesocial.com/papers/6a8c2742524f523decbbb59b https://doi.org/10.3109/10715762.2010.502170

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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