How to prevent glucocorticoid-induced osteoporosis

How to prevent glucocorticoid-induced osteoporosis ■ AbstrActWhen prescribing glucocorticoids for long-term treatment, physicians should take steps to prevent osteoporosis, a common and serious side effect of these drugs. ■ Key PointsGlucocorticoids have both direct and indirect effects on bone cells, and they both suppress bone formation and promote resorption.Patients who need glucocorticoids should receive the lowest effective dose for the shortest possible time.They should also be advised to undertake general health measures, including stopping smoking, reducing alcohol intake, exercising daily, and taking in adequate amounts of calcium and vitamin D.Bisphosphonates and teriparatide (Forteo) are approved for treating glucocorticoid-induced osteoporosis, but adherence to guidelines for managing this condition is far from optimal.