Affinity purification of Trypanosoma brucei small nuclear ribonucleoproteins reveals common and specific protein components.

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Population

Trypanosoma brucei extracts

Design

Preclinical

Authors

Discussion

Reveals principal protein differences in trypanosomal snRNPs; leaves open functional and therapeutic implications for parasites.

Population

Trypanosoma brucei extracts

Intervention

Affinity purification using biotinylated antisense 2'-O-methylated RNA oligonucleotides immobilized on streptavidin-agarose

Outcome

Protein components of U2 and U4/U6 snRNPs

Trypanosomal snRNPs exhibit principal differences from higher eukaryotic snRNPs in their protein components.

Pálfi et al. (1991) studied this question.

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