Population
Langendorff-perfused rat hearts subjected to calcium paradox
Comparison
Pretreatment with 20 mumol/l hydrogen peroxide vs Non-treated calcium paradox hearts
Design
Preclinical
Authors
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H2O2 pretreatment preserves LV function in Ca2+ paradox rat hearts; leaves open whether PKC-mediated protection applies to human myocardial injury.
Low concentration hydrogen peroxide protects against calcium paradox injury in rat hearts, a mechanism that appears to be mediated by protein kinase C signaling pathways.
Miyawaki et al. (1998) studied this question.
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