TRACES of keto-acid have been found to inhibit the in vitro reaction of the lactic and malic dehydrogenases of animal tissues with molecular oxygen [Green & Brosteaux, 1936; The oxidation of lactate or malate was found to proceed more or less linearly only in presence of reagents which can combine with keto-acids. Cyanide was the most efficient of all the ketone fixatives in the sense that the speed of oxidation of lactate or malate was several times as great in presence of cyanide as in presence of other fixatives such as hydrazine, hydroxylamine and semicarbazide.
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Green et al. (1937) studied this question.
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