Why the study?
Do milrinone and levosimendan improve ventricular function and haemodynamics in newborn compared to mature pigs?
Population
48 pigs in two age groups: newborn (5-6 days) and mature (5-6 weeks)
Comparison
Milrinone or levosimendan vs Control group
Design
Preclinical
Authors
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May induce hypotension without output gain in newborns; hypothesis-generating for age-specific inodilator use in human neonates.
Do milrinone and levosimendan improve ventricular function and haemodynamics in newborn compared to mature pigs?
Inodilators milrinone and levosimendan exhibit age-dependent haemodynamic effects, failing to increase cardiac output and causing hypotension in newborn pigs compared to mature pigs.
Hyldebrandt et al. (2011) studied this question.
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