Topically Applied Active Ingredients Establish an Equilibrium Dependent on Their Physico-Chemical Properties and a Skin Layer Specific Tissue Capacity

Topical administration presents an alternative route for targeted active ingredient delivery. Thus, an increasing demand for reliable ex vivo data to predict the outcome of in vivo skin penetration abilities of active ingredients arises. It is important to understand the impact of donor differences for percutaneous skin penetration studies and the influences of the physico-chemical properties of actives.