November 1, 1999British Journal of PharmacologyOpen Access

Voltage‐dependent block of normal and mutant muscle sodium channels by 4‐Chloro‐m‐Cresol

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Population

Heterologously expressed wild type, Paramyotonia Congenita and Hyperkalemic Periodic Paralysis mutant…

Comparison

4-Chloro-m-Cresol (4-CmC) vs Control conditions (absence of 4-CmC)

Design

Preclinical

Authors

GHGertrud HaeselerUniversity of Liverpool MLM. LeuwerNational Council for Scientific and Technological Development JKJ KavanMedizinische Hochschule Hannover

Discussion

Member takes

Implication

May support 4-CmC for myotonia therapy; hypothesis-generating in animal models only.

Structured PICO

Population

Heterologously expressed wild type (WT), Paramyotonia Congenita (R1448H) and Hyperkalemic Periodic Paralysis (M1360V) mutant alpha-subunits of human muscle sodium channels

Intervention

4-Chloro-m-Cresol (4-CmC)

Comparator

Control conditions (absence of 4-CmC)

Outcome

Sodium channel block (ECR50) and inactivation kineticssurrogate

4-CmC effectively blocks human muscle sodium channels and can restore normal inactivation kinetics in mutant channels associated with myotonia.

Cite This Study

Haeseler et al. (1999) studied this question.

synapsesocial.com/papers/6a8bc6442372d24d7cfb37d9 https://doi.org/10.1038/sj.bjp.0702896

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Voltage‐dependent block of normal and mutant muscle sodium channels by 4‐Chloro‐m‐Cresol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage‐dependent block of normal and mutant muscle sodium channels by 4‐Chloro‐m‐Cresol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider