October 1, 2003Pathology International

Cardiac ankyrin repeat protein is preferentially induced in atrophic myofibers of congenital myopathy and spinal muscular atrophy

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Population

25 cases, comprising 11 cases of spinal muscular atrophy and 14 cases of congenital myopathy.

Design

Case_series

Authors

CNChisato NakadaOita University AOAkira OkaSaitama Children's Medical Center INIkuya NonakaHeart Failure & Transplant

Discussion

Member takes

Implication

CARP immunohistochemistry may differentiate SMA from congenital myopathy subtypes; hypothesis-generating in a case report and needs validation before adoption.

Structured PICO

Population

25 cases, comprising 11 cases of spinal muscular atrophy (SMA) and 14 cases of congenital myopathy (including nemaline myopathy, myotubular myopathy, central core disease, and congenital fiber type disproportion).

Intervention

Immunohistochemical analysis of Cardiac ankyrin repeat protein (CARP) expression

Outcome

Expression patterns of CARP in skeletal musclesurrogate

Immunohistochemical evaluation of CARP expression may serve as a useful diagnostic marker for differentiating spinal muscular atrophy and specific subtypes of congenital myopathies.

Cite This Study

Nakada et al. (2003) studied this question.

synapsesocial.com/papers/6a8bc73efe910689a2893b24 https://doi.org/10.1046/j.1440-1827.2003.01541.x

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Implication

CARP immunohistochemistry may differentiate SMA from congenital myopathy subtypes; hypothesis-generating in a case report and needs validation before adoption.

Cardiac ankyrin repeat protein is preferentially induced in atrophic myofibers of congenital myopathy and spinal muscular atrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac ankyrin repeat protein is preferentially induced in atrophic myofibers of congenital myopathy and spinal muscular atrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider