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November 1, 1983Circulation ResearchOpen Access

Activation of contraction and ATPase activity in intact and chemically skinned smooth muscle of rat portal vein. Dependence on Ca++ and muscle length.

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Population

Intact and chemically skinned (Triton X-100) smooth muscle preparations of rat portal vein

Comparison

Activation by high potassium medium or calcium… vs Relaxed state (10 M Ca++) or varying levels of…

Design

Preclinical

Authors

AAAnders ArnerLund UniversityPHPer HellstrandLund University

Discussion

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Implication

Should not yet inform clinical vascular management; leaves open whether calcium-dependent energetics translate to human smooth muscle.

Structured PICO

P
Population
Intact and chemically skinned (Triton X-100) smooth muscle preparations of rat portal vein
I
Intervention
Activation by high potassium medium or calcium (with 1 microM calmodulin) at varying concentrations and muscle lengths
C
Comparator
Relaxed state (10(-9) M Ca++) or varying levels of calcium and muscle length
O
Outcome
Relationship between force development and ATPase activity (JATP) or oxygen consumptionsurrogate

This preclinical study elucidates the energy turnover dynamics of smooth muscle contraction in rat portal veins, showing how ATP consumption relates to force development under varying calcium concentrations and muscle lengths.

Cite This Study

Arner et al. (1983) studied this question.

synapsesocial.com/papers/6a8bc8d69ac394ad33cabac8https://doi.org/10.1161/01.res.53.5.695
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics of Ca2+- and Mg2+-induced tension development in chemically skinned smooth muscle fibers.1978 · 194 citations
  2. 2Contraction of the rat portal vein in hypertonic and isotonic medium: rates of metabolism1980 · 17 citations
  3. 3Effects of phasic and tonic activation on contraction dynamics in smooth muscle1980 · 26 citations
  4. 4Rate-limiting steps in the tension development of freeze-glycerinated vascular smooth muscle.1982 · 19 citations
  5. 5Relation between length, isometric force, and O2 consumption rate in vascular smooth muscle1975 · 70 citations