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April 1, 1972Acta Physiologica Scandinavica

Influence of Extracellular Calcium on Isometric Force and Velocity of Shortening in Depolarized Venous Smooth Muscle

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Population

Depolarized smooth muscle from rat portal vein

Design

Preclinical

Authors

PHPer HellstrandLund UniversityBJBörje JohanssonLund UniversityARAnita RingbergLund University

Discussion

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Implication

May refine venous smooth muscle models but should not alter clinical practice; leaves open human translation.

Structured PICO

P
Population
Depolarized smooth muscle from rat portal vein
I
Intervention
Extracellular calcium ([Ca++]0) at 2.5 mM or 0.4 mM
O
Outcome
Isometric force and velocity of shorteningsurrogate

In venous smooth muscle, extracellular calcium concentration regulates isometric force but does not affect the velocity of shortening at comparable relative loads.

Cite This Study

Hellstrand et al. (1972) studied this question.

synapsesocial.com/papers/6a8c26ea7239707559beeb42https://doi.org/10.1111/j.1748-1716.1972.tb05204.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relation between calcium and contraction kinetics in skinned muscle fibres1970 · 164 citations
  2. 2Force velocity relations of single cardiac muscle cells: calcium dependency.1977 · 63 citations
  3. 3Contraction in Venous Smooth Muscle Induced by Hypertonicity. Calcium Dependence and Mechanical Characteristics1974 · 33 citations
  4. 4The effect of calcium on the force‐velocity relation of briefly glycerinated frog muscle fibres1971 · 261 citations
  5. 5Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+.1990 · 100 citations