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February 1, 1974Acta Physiologica Scandinavica

Contraction in Venous Smooth Muscle Induced by Hypertonicity. Calcium Dependence and Mechanical Characteristics

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Population

Isolated rat portal vein

Comparison

Large increases in extracellular tonicity vs Isotonic medium (K+ contracture)

Design

Preclinical

Authors

CAChrister AnderssonLinköping UniversityPHPer HellstrandLund UniversityBJBörje JohanssonLund University

Discussion

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Implication

Hypertonicity may activate venous contraction via internal Ca2+ stores; leaves open relevance to human hyperosmolar vascular tone.

Structured PICO

P
Population
Isolated rat portal vein
I
Intervention
Large increases in extracellular tonicity (1.5-3 times normal)
C
Comparator
Isotonic medium (K+ contracture)
O
Outcome
Tension increase (active contraction vs passive shrinkage) and mechanical characteristicssurrogate

Hypertonicity induces active contraction in venous smooth muscle independent of membrane potential and external calcium.

Cite This Study

Andersson et al. (1974) studied this question.

synapsesocial.com/papers/6a9075bfe73a4c404fc9419ahttps://doi.org/10.1111/j.1748-1716.1974.tb05608.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Extracellular Calcium on Isometric Force and Velocity of Shortening in Depolarized Venous Smooth Muscle1972 · 34 citations
  2. 2Tension in Isolated Frog Muscle Fibers Induced by Hypertonic Solutions1973 · 55 citations
  3. 3Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle1968 · 31 citations
  4. 4Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle1968 · 79 citations
  5. 5Potassium accumulation in smooth muscle and associated ultrastructural changes1973 · 146 citations