Population
Rats with portal hypertension induced by partial ligation of the hepatic branches of the portal vein
Comparison
Alterations in extracellular Ca2+ concentration… vs Portal veins from sham-operated normal rats
Design
Preclinical
Follow-up
5 days (duration of hypertension before tissue extraction)
Authors
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Hypothesis-generating for venous hypertrophy mechanisms; requires human validation before clinical relevance.
Hypertrophic smooth muscle in rat portal veins exhibits lower isometric force and maximal shortening velocity, suggesting a reduced rate of cross-bridge turnover.
Arner et al. (1985) studied this question.
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