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December 15, 2017EP EuropaceOpen Access

The benefit of pacemaker therapy in patients with neurally mediated syncope and documented asystole: a meta-analysis of implantable loop recorder studies

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Why the study?

Does pacemaker therapy prevent syncope recurrence in patients with neurally mediated syncope and documented asystole?

Population

121 patients with neurally mediated syncope and documented asystole by implantable loop recorder who…

Design

Meta-analysis

Follow-up

up to 3 years

Authors

MBMichele BrignoleJDJean‐Claude DeharoCMC. Menozzi

Discussion

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Overview

(or to counsel them on recurrence risk).

Structured PICO

Does pacemaker therapy prevent syncope recurrence in patients with neurally mediated syncope and documented asystole?

P
Population
121 patients with neurally mediated syncope and documented asystole (mean duration 12.8 ± 11.0 s) by implantable loop recorder who received pacemaker therapy and had follow-up data available (pooled from 4 studies).
I
Intervention
Pacemaker therapy
O
Outcome
Syncope recurrencehard clinical

Pacemaker therapy is highly effective in preventing syncope recurrence in patients with neurally mediated syncope and ILR-documented asystole, particularly in those with a negative tilt test.

Cite This Study

Brignole et al. (2017) studied this question.

synapsesocial.com/papers/6a8bc8dd95f0361a9ebee10dhttps://doi.org/10.1093/europace/eux321
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Course of Symptoms and Spontaneous ECG in Pacemaker Patients: A 5‐Year Follow‐up Study1988 · 30 citations
  2. 2Syncope in patients paced for atrioventricular block2016 · 35 citations
  3. 3Implications of mechanism of bradycardia on response to pacing in patients with unexplained syncope2007 · 68 citations
  4. 4Assessment of a standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncopes2015 · 80 citations
  5. 5Twenty-eight years of research permit reinterpretation of tilt-testing: hypotensive susceptibility rather than diagnosis2014 · 128 citations