Why the study?
Aspirin is noninferior to other anticoagulants for preventing postoperative venous thromboembolism after lower extremity arthroplasty or revision, but its optimal dosing is unclear.
Do lower doses of aspirin (81, 162, or 325 mg) reduce bleeding compared to 650 mg in patients undergoing lower extremity joint arthroplasty or revision?
Do lower doses of aspirin (81, 162, or 325 mg) reduce bleeding compared to 650 mg in patients undergoing lower extremity joint arthroplasty or revision?
In patients undergoing lower extremity joint arthroplasty, varying doses of prophylactic aspirin from 81 mg to 650 mg daily resulted in similar rates of bleeding and venous thromboembolism.
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Comparable bleeding across aspirin doses in arthroplasty; hypothesis-generating and should not yet change practice.
Watts et al. (2021) studied this question.
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