July 1, 1999Clinical Pharmacology & Therapeutics

Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects

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Why the study?

Does an accelerated titration regimen of sotalol safely shorten the time to achieve target QTc prolongation compared to standard titration in healthy middle-aged subjects?

Population

34 healthy, middle-aged sedentary men and women

Comparison

Accelerated titration regimen: placebo every 6… vs Standard titration: placebo alternating with 80…

Design

RCT, double-blind

Authors

JBJean T. BarbeyTulane University MSMark SaleUniversity of North Texas RWRaymond L. WoosleyElectrophysiology

Discussion

Member takes

Implication

Accelerated sotalol titration may shorten inpatient monitoring by nearly a day; extends RCT evidence to support regimen optimization in practice.

Structured PICO

Does an accelerated titration regimen of sotalol safely shorten the time to achieve target QTc prolongation compared to standard titration in healthy middle-aged subjects?

Population

34 healthy, middle-aged sedentary men and women

Intervention

Accelerated titration regimen: placebo every 6 hours for four doses, followed by 80 mg sotalol every 6 hours for four doses, then 160 mg sotalol every 12 hours for nine doses

Comparator

Standard titration: placebo alternating with 80 mg sotalol every 6 hours for eight doses, followed by 160 mg sotalol every 12 hours for nine doses

Outcome

Time to achieve target prolongation of QTc (90% of the value achieved at steady state)surrogate

An accelerated titration regimen of sotalol safely shortens the time to achieve target QTc prolongation by nearly a day without excessive QT prolongation, potentially reducing hospital stay.

Cite This Study

Barbey et al. (1999) studied this question.

synapsesocial.com/papers/6a8bca3ef71b672e3df49897 https://doi.org/10.1016/s0009-9236(99)70058-5

View Full Paper

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Implication

Accelerated sotalol titration may shorten inpatient monitoring by nearly a day; extends RCT evidence to support regimen optimization in practice.

Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider