Population
Mathematical model of heterogeneous myocardial muscle fiber
Design
Other
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Model findings on fiber heterogeneity should not change practice; leaves open whether this modulates in vivo myocardial remodeling under load.
A mathematical model demonstrates that local heterogeneity in geometrical and mechanical parameters significantly influences the mechanical response of myocardial muscle fibers, suggesting a mechanism that may modulate myocardial remodeling under changing loads.
Smoluk et al. (2014) studied this question.
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