Influence of myocardial fiber/sheet orientations on left ventricular mechanical contraction
Population
Electro-mechanically coupled computational models of the left ventricle
Comparison
Heterogeneous model assigning orthotropic tissue… vs Generic homogeneous model using a rule-based…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Heterogeneous properties are required for accurate LV torsion predictions in models; leaves open clinical translation in humans.
Structured PICO
P
Population
Electro-mechanically coupled computational models of the left ventricle
I
Intervention
Heterogeneous model assigning orthotropic tissue structure based on experimentally obtained fiber/sheet orientations
C
Comparator
Generic homogeneous model using a rule-based method to assign fiber and sheet orientations
O
Outcome
Predicted deformations (particularly torsion), pressure-volume loops, and metrics of global mechanical functionsurrogate
Heterogeneous structural properties significantly impact predicted left ventricular deformations, particularly torsion, highlighting the need to include them in computational models.
Cite This Study
Prassl et al. (2013) studied this question.