October 1, 2014PLoS ONEOpen Access

Calcium-Activated Potassium Current Modulates Ventricular Repolarization in Chronic Heart Failure

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Structured PICO

Population

Canine tachypacing induced model of HF (1 and 4 months, n = 5 per group), 4 month HF with 6 weeks of superimposed atrial fibrillation (n = 7), age-matched canine controls (n = 8). Human atrial and ventricular myocytes isolated from explanted end-stage failing hearts.

Intervention

I(KCa) blocker (apamin 100 nM)

Comparator

Controls (no HF) and baseline without blockade

Outcome

Cellular electrophysiologic effects (action potential repolarization)surrogate

I(KCa) blockade in ventricular myocytes during chronic heart failure results in cellular arrhythmias, suggesting I(KCa) plays an important role in maintaining ventricular repolarization stability.

Discussion

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Implication

I(KCa) may stabilize repolarization in HF; animal data leave open clinical relevance of blockade.

Cite This Study

Bonilla et al. (2014) studied this question.

synapsesocial.com/papers/6a8bcafa0ca85c7e33df0c64 https://doi.org/10.1371/journal.pone.0108824

Topics

Heart failure HFrEF treatment Atrial fibrillation Persistent AF management

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Calcium-Activated Potassium Current Modulates Ventricular Repolarization in Chronic Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

Calcium-Activated Potassium Current Modulates Ventricular Repolarization in Chronic Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider