Why the study?
Hyperthyroidism represents a hypercoagulable and hypofibrinolytic state predisposing individuals to increased thromboembolism risk.
This case highlights the potential for active thyrotoxicosis in Graves' disease to induce a prothrombotic state, leading to early-onset myocardial infarction.
May prompt thyroid evaluation in young MI patients; hypothesis-generating for thyrotoxicosis-induced thrombosis.
Hyperthyroidism represents a state of hypercoagulability and hypofibrinolysis, which predisposes an individual to the increased risk of thromboembolism. We present a case of a 25-year-old patient presenting with an acute myocardial infarction secondary to plaque rupture with thrombotic occlusion of proximal left anterior descending artery, in a patient known to have Graves' disease. She had a sudden ventricular fibrillation arrest and a precordial thump given and cardiopulmonary resuscitation started. She successfully underwent cardiac catheterisation. Subsequent thyroid function tests showed she was in active thyrotoxicosis.
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Dixey et al. (2021) studied this question.
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