Why the study?
Does congenital heart disease alter head biometry and brain perfusion in second-trimester fetuses compared to normal matched controls?
Population
190 fetuses in the second trimester of pregnancy, comprising 95 consecutive fetuses diagnosed with…
Comparison
Congenital heart disease (CHD) vs Normal fetuses matched for gestational age
Design
Case-control
Authors
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Supports early brain perfusion changes in second-trimester CHD; hypothesis-generating for neurodevelopmental risk and prospective validation studies.
Does congenital heart disease alter head biometry and brain perfusion in second-trimester fetuses compared to normal matched controls?
Fetuses with congenital heart disease exhibit smaller head biometry and increased brain perfusion as early as the second trimester, suggesting early onset of mechanisms that may lead to poorer neurodevelopment.
Masoller et al. (2014) studied this question.
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