July 20, 2022Evidence-based Complementary and Alternative MedicineOpen Access

Qige Huxin Formula Attenuates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Protecting Intestinal Integrity

View Full Paper

Ask AI

Bookmark

Why the study?

It was unclear whether Qige Huxin formula alleviates cardiac fibrosis by modulating gut microbiota and intestinal integrity.

Does Qige Huxin formula alleviate isoprenaline-induced cardiac fibrosis in mice?

Population

Fifty mice with isoprenaline-induced cardiac fibrosis

Comparison

Low-dose QHF vs high-dose QHF vs control vs model vs meto group

Design

Randomized preclinical animal study

Authors

LSLipeng ShiFirst People's Hospital of Chongqing XDXuqin DuChongqing University BZBiao ZuoFirst People's Hospital of Chongqing

Discussion

Member takes

Implication

QHF effects remain hypothesis-generating in mice; leaves open translation to human cardiac fibrosis or clinical use.

Structured PICO

Does Qige Huxin formula alleviate isoprenaline-induced cardiac fibrosis in mice?

Population

50 mice with isoprenaline-induced cardiac fibrosis (10 mg/kg/d for 14 days)

Intervention

Qige Huxin formula (QHF) at 2.56 g/kg/d (low-dose) or 5.12 g/kg/d (high-dose)

Comparator

Control group, model group (isoprenaline only), and metoprolol group (15 mg/kg/d)

Outcome

Heart volume, cardiac weight index (CWI), serum myocardial enzymes, serum inflammatory cytokines, serum lipopolysaccharide, histopathology of the heart and colon tissues, ZO-1, occludin, and gut microbiota compositionsurrogate

Qige Huxin formula attenuates isoprenaline-induced cardiac fibrosis in mice, potentially by modulating gut microbiota and protecting intestinal integrity.

Cite This Study

Shi et al. (2022) studied this question.

synapsesocial.com/papers/6a8bcc498c2084202833b03e https://doi.org/10.1155/2022/2894659

View Full Paper

Ask AI

Bookmark

Qige Huxin Formula Attenuates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Protecting Intestinal Integrity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Qige Huxin Formula Attenuates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Protecting Intestinal Integrity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider