November 1, 1997BJOG An International Journal of Obstetrics & Gynaecology

Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies

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Why the study?

Do women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities?

Population

62 women without hypertensive disorders either before or during pregnancy, consecutively admitted with…

Design

Cohort

Follow-up

>10 weeks after delivery for testing; 6 weeks for vitamin…

Authors

JVJohanna I.P. de VriesAmsterdam University Medical Centers GDG.A. DekkerLyell McEwin Hospital PHP. C. Huijgensb

Discussion

Member takes

Implication

Supports consideration of postpartum thrombophilia screening after complicated pregnancies; hypothesis-generating for prospective validation.

Structured PICO

Do women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities?

Population

62 women without hypertensive disorders either before or during pregnancy, consecutively admitted with placental abruption (n=31), intrauterine fetal death (n=18), or a small for gestational age infant (n=13).

Intervention

Screening for metabolic and haemostatic abnormalities; subset with hyperhomocysteinaemia received daily oral dose of 250 mg pyridoxine and 5 mg folic acid for 6 weeks.

Outcome

Presence of hyperhomocysteinaemia, various coagulation abnormalities, and anticardiolipins.surrogate

Women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities, suggesting a need for postpartum screening.

Cite This Study

Vries et al. (1997) studied this question.

synapsesocial.com/papers/6a8bcd350ca85c7e33df0d0c https://doi.org/10.1111/j.1471-0528.1997.tb10970.x

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November 1, 1997BJOG An International Journal of Obstetrics & Gynaecology

Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies

View Full Paper

Ask AI

Bookmark

Why the study?

Do women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities?

Population

62 women without hypertensive disorders either before or during pregnancy, consecutively admitted with…

Design

Cohort

Follow-up

>10 weeks after delivery for testing; 6 weeks for vitamin…

Authors

JVJohanna I.P. de VriesAmsterdam University Medical Centers GDG.A. DekkerLyell McEwin Hospital PHP. C. Huijgensb

Discussion

Member takes

Implication

Supports consideration of postpartum thrombophilia screening after complicated pregnancies; hypothesis-generating for prospective validation.

Structured PICO

Do women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities?

Population

Intervention

Screening for metabolic and haemostatic abnormalities; subset with hyperhomocysteinaemia received daily oral dose of 250 mg pyridoxine and 5 mg folic acid for 6 weeks.

Outcome

Presence of hyperhomocysteinaemia, various coagulation abnormalities, and anticardiolipins.surrogate

Women with complicated pregnancies have a high prevalence of metabolic and haemostatic abnormalities, suggesting a need for postpartum screening.

Cite This Study

Vries et al. (1997) studied this question.

synapsesocial.com/papers/6a8bcd350ca85c7e33df0d0c https://doi.org/10.1111/j.1471-0528.1997.tb10970.x

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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