Why the study?
Is high molecular weight angiotensinogen (HMrA) a good substrate for human renin compared to low molecular weight angiotensinogen (LMrA)?
Population
In vitro biochemical model using human renin and human high and low molecular weight angiotensinogen
Comparison
Reaction of human renin with high molecular… vs Reaction of human renin with low molecular…
Design
Preclinical
Authors
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Animal data on pH-dependent renin activity leave open any distinct role for HMrA in pregnancy hypertension; no clinical implications.
Is high molecular weight angiotensinogen (HMrA) a good substrate for human renin compared to low molecular weight angiotensinogen (LMrA)?
High molecular weight angiotensinogen is a viable substrate for human renin, suggesting it plays a significant role in the renin-angiotensin system where it is highly concentrated, such as in pregnancy.
Tryon et al. (1995) studied this question.
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