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January 1, 1991British Journal of PharmacologyOpen Access

Effect of endothelium removal on the vasoconstrictor response to neuronally released 5‐hydroxytryptamine and noradrenaline in the rat isolated mesenteric and femoral arteries

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Population

Isolated ring segments of rat mesenteric and femoral arteries

Comparison

Removal of the endothelium vs Intact endothelium

Design

Preclinical

Authors

MUMasanobu UrabeUniversity of MiyazakiHKHiromu KawasakiOkayama UniversityKTK. TakasakiRoche (Switzerland)

Discussion

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Implication

Endothelium may selectively modulate NA- but not 5-HT-mediated neurogenic tone in animal vessels; leaves open translation to human vasoregulation.

Structured PICO

P
Population
Isolated ring segments of rat mesenteric and femoral arteries
I
Intervention
Removal of the endothelium
C
Comparator
Intact endothelium
O
Outcome
Vasoconstrictor response to transmural nerve stimulation (TNS) mediated by endogenous noradrenaline (NA) and 5-hydroxytryptamine (5-HT)surrogate

Endothelial cells regulate neurogenic vasoconstriction mediated by noradrenaline by releasing endothelium-derived relaxing factor, but do not affect the response to neuronally released 5-HT.

Cite This Study

Urabe et al. (1991) studied this question.

synapsesocial.com/papers/6a8bd1192ff0ab4f91e95bfbhttps://doi.org/10.1111/j.1476-5381.1991.tb12136.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium‐derived relaxant factor.1984 · 120 citations
  2. 2Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.1987 · 5,095 citations