November 1, 2000AJP Regulatory Integrative and Comparative Physiology

Na+/Ca2+-exchange activity regulates contraction and SR Ca2+content in rainbow trout atrial myocytes

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Structured PICO

Population

Rainbow trout atrial myocytes

Intervention

Modulation of Na+/Ca2+ exchanger (NCX) activity via varying pipette Na+ concentrations (16, 10, 0 mM), exchanger inhibitory peptide (XIP), and nifedipine

Comparator

Control conditions (e.g., 16 mM Na+ pipette concentration, absence of inhibitors)

Outcome

Sarcolemmal Ca2+ transport, cell shortening, and sarcoplasmic reticulum (SR) Ca2+ contentsurrogate

Modulation of NCX activity critically determines Ca2+ entry, cell shortening, and SR Ca2+ content in rainbow trout atrial myocytes.

Discussion

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Implication

NCX shapes Ca2+ handling in trout atrial myocytes; extends comparative mechanisms but leaves open mammalian translation.

Cite This Study

Hove‐Madsen et al. (2000) studied this question.

synapsesocial.com/papers/6a8bd307b676b7d1a2fb7f05 https://doi.org/10.1152/ajpregu.2000.279.5.r1856

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Na+/Ca2+-exchange activity regulates contraction and SR Ca2+content in rainbow trout atrial myocytes

Structured PICO

Discussion

Implication

Cite This Study

Na+/Ca2+-exchange activity regulates contraction and SR Ca2+content in rainbow trout atrial myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider