Why the study?
Does blockade of one of the main bronchi alter ventilation, perfusion, and PaO2 in anaesthetized patients?
Does blockade of one of the main bronchi alter ventilation, perfusion, and PaO2 in anaesthetized patients?
Blockade of a main bronchus in anaesthetized patients leads to a fall in PaO2, with differential effects on lung perfusion depending on whether the right or left bronchus is blocked.
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May lower PaO2 with right-left perfusion asymmetry during bronchial blockade; hypothesis-generating for one-lung ventilation physiology.
An attempt has been made to evaluate the magnitude of and changes in the right-left shunt following 40 minutes' blockade of one of the main bronchi in 6 anaesthetized patients, of whom 3 had the right and 3 the left bronchus blocked. Xenon133 was used together with a simple transportable apparatus employing four collimators on the anterior of the thorax. Despite verified blockade (bronchoscopy and stethoscopy), the study showed an activity corresponding to a ventilation of approximately one-third of the initial values. It was not possible to demonstrate any fall in the perfusion on the blocked side following blockade of the left main bronchus, whereas blockade of the right main bronchus produced a calculated fall to two-thirds of the initial perfusion. The blockade caused a fall in PaO2 in all the patients, which was inpendent upon the side blocked and of a magnitude that corresponded to the perfusion measured after blockade of the right main bronchus.
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Svendsen et al. (1974) studied this question.
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